Pyridine → tert-Butyl 3-carbamoylmorpholine-4-carboxylate

HRID 1351345

반응식

HRID 1351345 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH:9]1[C:14]([OH:16])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[N:17]1C=CC=CC=1.C(OC(OC(C)(C)C)=O)(OC(C)(C)C)=O>O1CCOCC1>[NH2:17][C:14]([CH:9]1[CH2:10][O:11][CH2:12][CH2:13][N:8]1[C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])=[O:16]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 90495Di-tert-butyl dicarbonateHCID 27601334-(tert-Butoxycarbonyl)morpholine-3-carboxylic acid

생성물 1

HCID 21098189tert-Butyl 3-carbamoylmorpholine-4-carboxylate

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a stirred solution of the compound prepared in Step 1 (1 eq.), pyridine (0.6 eq.) and di-t-butyl dicarbonate (1.3 eq.) in dioxane (0.6 M), NH4HCO3 (1.26 eq.) was added and the mixture was stirred at room temperature for 20 hours. Mixture was concentrated, taken up in EtOAc and washed with water and brine. Organics were dried over Na2SO4 and evaporated giving the title product as an oil which crystallized at room temperature.

후처리

  1. concentrationMixture was concentrated
  2. washwashed with water and brine
  3. dry with materialOrganics were dried over Na2SO4
  4. customevaporated

출처 및 근거

ORD 기록
ord-f2efb6265014408f8e189eb547b261b0
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07217713B2

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