Triethylamine → 5-(4-Methylpiperazin-1-yl)-2-nitroaniline

HRID 13520

반응식

HRID 13520 반응식
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.CN1C(=O)CCC1.C(N(CC)CC)C.F[C:23]1[CH:24]=[CH:25][C:26]([N+:30]([O-:32])=[O:31])=[C:27]([NH2:29])[CH:28]=1>O>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:23]2[CH:24]=[CH:25][C:26]([N+:30]([O-:32])=[O:31])=[C:27]([NH2:29])[CH:28]=2)[CH2:4][CH2:3]1

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 13387N-methyl-2-pyrrolidoneHCID 531671-MethylpiperazineHCID 753995-Fluoro-2-nitroaniline

생성물 1

HCID 27600345-(4-Methylpiperazin-1-yl)-2-nitroaniline

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of N-methylpiperazine (1.0 eq), NMP, triethylamine (3.0 eq) and 5-fluoro-2-nitrophenylamine (1.0 eq) were heated at 90° C. for 1 hours. The reaction was allowed to cool to room temperature and then poured into water and let stand for 12 hours. The resulting solid was collected and dried and utilized without further purification. MH+=237.3.

후처리

  1. customThe resulting solid was collected
  2. customdried
  3. customutilized without further purification

출처 및 근거

ORD 기록
ord-912e0e0b843a42cba63f5551c1645ee6
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728010B2

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