Triethylamine → 5-(4-Methylpiperazin-1-yl)-2-nitroaniline
반응식
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.CN1C(=O)CCC1.C(N(CC)CC)C.F[C:23]1[CH:24]=[CH:25][C:26]([N+:30]([O-:32])=[O:31])=[C:27]([NH2:29])[CH:28]=1>O>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:23]2[CH:24]=[CH:25][C:26]([N+:30]([O-:32])=[O:31])=[C:27]([NH2:29])[CH:28]=2)[CH2:4][CH2:3]1참가 물질
6
실험 절차
A solution of N-methylpiperazine (1.0 eq), NMP, triethylamine (3.0 eq) and 5-fluoro-2-nitrophenylamine (1.0 eq) were heated at 90° C. for 1 hours. The reaction was allowed to cool to room temperature and then poured into water and let stand for 12 hours. The resulting solid was collected and dried and utilized without further purification. MH+=237.3.
후처리
- customThe resulting solid was collected
- customdried
- customutilized without further purification
출처 및 근거
- ORD 기록
- ord-912e0e0b843a42cba63f5551c1645ee6
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07728010B2
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