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4-Methylcyclohexylamine → 7-Chloro-4-[4-[(4-methylcyclohexyl)aminocarbonyl]piperazin-1-yl]quinoline

HRID 1353408
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인쇄 미리보기

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HRID 1353408 반응식
[CH3:1][CH:2]1[CH2:7][CH2:6][CH:5]([NH2:8])[CH2:4][CH2:3]1.Cl[C:10](OC1C=CC([N+]([O-])=O)=CC=1)=[O:11].C(N(C(C)C)CC)(C)C.[Cl:31][C:32]1[CH:41]=[C:40]2[C:35]([C:36]([N:42]3[CH2:47][CH2:46][NH:45][CH2:44][CH2:43]3)=[CH:37][CH:38]=[N:39]2)=[CH:34][CH:33]=1>C(Cl)Cl.CO>[Cl:31][C:32]1[CH:41]=[C:40]2[C:35]([C:36]([N:42]3[CH2:47][CH2:46][N:45]([C:10]([NH:8][CH:5]4[CH2:6][CH2:7][CH:2]([CH3:1])[CH2:3][CH2:4]4)=[O:11])[CH2:44][CH2:43]3)=[CH:37][CH:38]=[N:39]2)=[CH:34][CH:33]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 806044-MethylcyclohexylamineHCID 81531DiisopropylethylamineHCID 821294-Nitrophenyl chloroformateHCID 7383897-Chloro-4-(piperazin-1-yl)quinoline

생성물 1

HCID 211017307-Chloro-4-[4-[(4-methylcyclohexyl)aminocarbonyl]piperazin-1-yl]quinoline

시약·촉매·용매 1

HCID 21226129
Dichloromethane methanol
용매

실험 절차

As described for example 78, 4-methylcyclohexylamine (206.1 mg, 1.82 mmol), 4-nitrophenyl chloroformate (366 mg, 1.82 mmol), diisopropyl(ethyl)amine (554 mg, 4.3 mmol), and 7-chloro-4-(piperazin-1-yl)quinoline (300 mg, 1.21 mmol) are reacted affording the title product after flash chromatography with CH2Cl2-MeOH.

후처리

  1. customare reacted

출처 및 근거

ORD 기록
ord-90e7e55c012340a89f5ffca740f1d2f0
출처 데이터셋
uspto-grants-2007_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07220856B2

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