Tetrahydrofuran → 6-(4-Biphenylylmethoxy)nicotinic Acid

HRID 1356447노트

반응식

HRID 1356447 반응식
[C:1]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:6]=[CH:5][C:4]([CH2:7][O:8][C:9]2[CH:18]=[CH:17][C:12]([C:13]([O:15]C)=[O:14])=[CH:11][N:10]=2)=[CH:3][CH:2]=1.C1COCC1>CO.[OH-].[Na+].Cl>[C:1]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:6]=[CH:5][C:4]([CH2:7][O:8][C:9]2[CH:18]=[CH:17][C:12]([C:13]([OH:15])=[O:14])=[CH:11][N:10]=2)=[CH:3][CH:2]=1

참가 물질

6

반응물 2

HCID 8028TetrahydrofuranHCID 18508353Methyl 6-(4-biphenylylmethoxy)nicotinate

생성물 1

HCID 178174806-(4-Biphenylylmethoxy)nicotinic Acid수율 83.7%

시약·촉매·용매 3

HCID 313Hydrochloric Acid용매HCID 887Methanol용매HCID 14798Sodium Hydroxide용매

실험 절차

To a solution of methyl 6-(4-biphenylylmethoxy)nicotinate (2.0 g) in methanol (20 ml)/THF(40 ml) was added iN aqueous sodium hydroxide (13 ml) at room temperature. After stirring at room temperature for 4 hr the reaction mixture was diluted with 1 N hydrochloric acid (13 ml) and concentrated. The precipitate was collected by filtration and washed with water and diethyl ether sequentially to obtain the titled compound (1.6 g) as amorphous powder.

후처리

  1. concentrationconcentrated
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water and diethyl ether sequentially

출처 및 근거

ORD 기록
ord-dfbdd527ca69446aba9847ef571372c9
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06586475B1

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