Methanol → methyl (2S)-4-methyl-2-(methylamino)pentanoate

HRID 1356519

반응식

HRID 1356519 반응식
[CH3:1][NH:2][C@H:3]([C:8]([OH:10])=[O:9])[CH2:4][CH:5]([CH3:7])[CH3:6].O1CCOC[CH2:12]1.CO>Cl>[CH3:12][O:9][C:8](=[O:10])[C@H:3]([CH2:4][CH:5]([CH3:7])[CH3:6])[NH:2][CH3:1]

참가 물질

5

반응물 3

HCID 887MethanolHCID 312751,4-DioxaneHCID 2777993N-Methylleucine

생성물 1

HCID 10921446methyl (2S)-4-methyl-2-(methylamino)pentanoate수율 100%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

N-methyl-L-leucine (1.3 g, 8.95 mmol) was dissolved in 4M HCl, 1,4 dioxane (10 mL) and methanol (10 mL). The solution was stirred overnight at room temperature, then concentrated to afford the title compound as a white solid (100%). MS (ESI): 160.0 (M+H)+.

후처리

  1. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c84cddade0974f8e87532868bc68310d
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06586466B2

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