Water → 4-Azidobenzaldehyde

HRID 1358152

반응식

HRID 1358152 반응식
F[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.[N-:10]=[N+:11]=[N-:12].[Na+].O>CS(C)=O>[N:10]([C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1)=[N+:11]=[N-:12]

참가 물질

5

반응물 3

HCID 962WaterHCID 33557Sodium AzideHCID 680234-Fluorobenzaldehyde

생성물 1

HCID 903854-Azidobenzaldehyde

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

반응 조건

온도
105 °C

실험 절차

50 g 4-fluoro benzaldehyde and 50 g sodium azide were dispersed in 150 ml dry dimethyl sulfoxide. Subsequently, the mixture was heated for 3 hours at 105° C. while nitrogen was introduced. The mixture was poured into 200 ml water, and the solution extracted with 200 ml dichloro methane (three times). Then the solvent was distilled off by means of a vacuum rotation vaporizer. 53 g of a liquid remained having infrared (IR) and nuclear magnetic resonance (NMR) spectra consistent with the 4-azido benzaldehyde structure.

후처리

  1. additionwas introduced
  2. extractionthe solution extracted with 200 ml dichloro methane (three times)
  3. distillationThen the solvent was distilled off by means of a vacuum rotation vaporizer

출처 및 근거

ORD 기록
ord-83d9711f65f642a6b84fcbd04a7e823b
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06596460B2

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