2-Nitrophenol → Benzyl-2-nitrophenyl Ether

HRID 1358456

반응식

HRID 1358456 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1O)([O-:3])=[O:2].[C:11]([O-:14])([O-])=O.[K+].[K+].[CH2:17](Cl)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>O>[CH2:17]([C:5]1[C:4]([N+:1]([O-:3])=[O:2])=[C:9]([O:14][C:11]2[CH:8]=[CH:7][CH:6]=[C:5]([CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:4]=2[N+:1]([O-:3])=[O:2])[CH:8]=[CH:7][CH:6]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

5

반응물 3

HCID 69472-NitrophenolHCID 7503Benzyl ChlorideHCID 11430Potassium Carbonate

생성물 1

HCID 57359178Benzyl-2-nitrophenyl Ether

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

A mixture of 2-nitrophenol (27.82 g˜0.18 mol, Lancaster, contains ca 10% H2O), K2CO3 (33.15 g, 0.24 mol), and benzyl chloride (30.38 g, 27.6 ml, 0.24 mol) was heated at 100° C. for 1.5 h. The resulting mixture was poured in 1.3 L of water and extracted with CHCl3 tree times, washed twice with 50% brine, dried with Na2SO4, filtered and concentrated. Distillation in vacuum gave 39.23 g (96%), bp 161-162° C. (˜0.1 mm Hg).

후처리

  1. extractionextracted with CHCl3 tree times
  2. washwashed twice with 50% brine
  3. dry with materialdried with Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated
  6. distillationDistillation in vacuum
  7. customgave 39.23 g (96%), bp 161-162° C. (˜0.1 mm Hg)

출처 및 근거

ORD 기록
ord-3f1355235afc4195a10996996216cf34
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06596734B1

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