Sodium hydride → 4-Trifluoromethylthiobenzyl 4-trifluoromethylsulfonylphenyl ether

HRID 1358738

반응식

HRID 1358738 반응식
[F:1][C:2]([F:13])([F:12])[S:3][C:4]1[CH:11]=[CH:10][C:7]([CH2:8][OH:9])=[CH:6][CH:5]=1.[F:14][C:15]([F:27])([F:26])[S:16]([C:19]1[CH:24]=[CH:23][C:22](Cl)=[CH:21][CH:20]=1)(=[O:18])=[O:17].[H-].[Na+]>>[F:26][C:15]([F:14])([F:27])[S:16]([C:19]1[CH:24]=[CH:23][C:22]([O:9][CH2:8][C:7]2[CH:10]=[CH:11][C:4]([S:3][C:2]([F:12])([F:1])[F:13])=[CH:5][CH:6]=2)=[CH:21][CH:20]=1)(=[O:17])=[O:18]

참가 물질

4

반응물 3

HCID 24758Sodium hydrideHCID 7033241-Chloro-4-(trifluoromethylsulfonyl)benzeneHCID 27778704-((Trifluoromethyl)thio)benzenemethanol

생성물 1

HCID 181853274-Trifluoromethylthiobenzyl 4-trifluoromethylsulfonylphenyl ether수율 66.7%

실험 절차

4-(Trifluoromethylthio)benzyl alcohol (300 mg, 1.44 mmol) was coupled with 4-(trifluoromethylsulfonyl)chlorobenzene (370 mg, 1.51 mmol) using sodium hydride (65 mg, 60% dispersion in oil, 1.58 mmol) to give 400 mg of 4-trifluoromethylthiobenzyl 4-trifluoromethylsulfonylphenyl ether as a white solid. 1HNMR (360 MHz, DMSO-d6) δ 8.06 (d, J=8.4 Hz, 2H), 7.77 (d, J=8.4 Hz, 2H), 7.63 (d, J=8.4 Hz, 2H), 7.43 (d, J=8.4 Hz, 2H), 5.39 (s, 2H, OCH2).

출처 및 근거

ORD 기록
ord-66643039a25840489d0b0e062542870d
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06596772B1

연결된 노트

불러오는 중…