Salicyl Alcohol → [2-(2-Morpholinoethoxy)phenyl]methanol

HRID 1359664

반응식

HRID 1359664 반응식
[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5].Cl.Cl[CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>[OH-].[Na+]>[N:14]1([CH2:13][CH2:12][O:1][C:2]2[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=2[CH2:4][OH:5])[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1

참가 물질

4

반응물 2

HCID 5146Salicyl AlcoholHCID 77210Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)

생성물 1

HCID 7164615[2-(2-Morpholinoethoxy)phenyl]methanol

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

A mixture of 2-hydroxybenzyl alcohol (1.295 g, 10.4 mmol) and 4-(2-chloroethyl)morpholine hydrochloride (1.94 g, 10.4 mmol) in 2N NaOH (10.5 mL) was stirred at rt for 14 hours. The precipitate was collected by vacuum filtration, washed with 1N NaOH, redissolved in DCM and washed with 1N NaOH. The aqueous layer was extracted with more DCM (2×). The combined DCM was dried and concentrated to give [2-(2-morpholin-4-yl-ethoxy)-phenyl]-methanol which was used without further purification.

후처리

  1. filtrationThe precipitate was collected by vacuum filtration
  2. washwashed with 1N NaOH
  3. dissolutionredissolved in DCM
  4. washwashed with 1N NaOH
  5. extractionThe aqueous layer was extracted with more DCM (2×)
  6. dry with materialThe combined DCM was dried
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-7b584bb1f44649918b9acb5561442590
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06599902B2

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