Hydrochloric Acid → 4-(Benzyloxy)-3-nitrobenzoic acid

HRID 1360254

반응식

HRID 1360254 반응식
C[O:2][C:3](=[O:21])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:6]([N+:18]([O-:20])=[O:19])[CH:5]=1.CO.[OH-].[K+].Cl>O1CCCC1>[CH2:11]([O:10][C:7]1[CH:8]=[CH:9][C:4]([C:3]([OH:21])=[O:2])=[CH:5][C:6]=1[N+:18]([O-:20])=[O:19])[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14797Potassium HydroxideHCID 289857Methyl 4-benzyloxy-3-nitrobenzoate

생성물 1

HCID 161247254-(Benzyloxy)-3-nitrobenzoic acid수율 95%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution the crude 4-benzyloxy-3-nitro-benzoic acid methyl ester from the previous step in tetrahydrofurane (150 mL) and MeOH (600 mL) was treated with KOH 3N (152 mL) and stirred at room temperature for 18 hours. The mixture was acidified with HCl 3N. The precipitate thus formed was filtered, washing with MeOH/water 1:1 and dried under vacuum. 4-Benzyloxy-3-nitro-benzoic acid (42 g, 95% over two steps) was obtained as a white solid, which was used crude in the following reaction.

후처리

  1. customThe precipitate thus formed
  2. filtrationwas filtered
  3. washwashing with MeOH/water 1:1
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-67d2cc2522e543f08b13be6214d4fa13
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07879845B2

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