Hydrochloric Acid → 2,3-Difluorophenyl propionate

HRID 1362498

반응식

HRID 1362498 반응식
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[OH:9].[C:10](Cl)(=[O:13])[CH2:11][CH3:12].Cl>ClCCl.N1C=CC=CC=1>[C:10]([O:9][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([F:8])[C:2]=1[F:1])(=[O:13])[CH2:11][CH3:12]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 62324Propionyl chlorideHCID 808792,3-Difluorophenol

생성물 1

HCID 669694902,3-Difluorophenyl propionate수율 105.2%

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 6344Dichloromethane용매

실험 절차

20 g (153.7 mmol) of 2,3-difluorophenol in 150 ml of dichloromethane and 17.5 ml of pyridine are admixed dropwise at 0° C. with 14 ml (161 mmol) of propionyl chloride. The mixture is stirred for two hours and 100 ml of 2 M hydrochloric acid are added. The mixture is extracted with dichloromethane and the extracts are washed with water. Drying over sodium sulphate and the removal of the solvent in vacuo give 30.1 g of 2,3-difluorophenyl propionate.

후처리

  1. extractionThe mixture is extracted with dichloromethane
  2. washthe extracts are washed with water
  3. dry with materialDrying over sodium sulphate
  4. customthe removal of the solvent in vacuo

출처 및 근거

ORD 기록
ord-f81e89d20163424890f98d077e8c1f16
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07880042B2

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