Water → 7-Methoxy-2,3-dihydrobenzofuran-3-ol

HRID 1364413

반응식

HRID 1364413 반응식
[CH3:1][O:2][C:3]1[C:11]2[O:10][CH2:9][C:8](=[O:12])[C:7]=2[CH:6]=[CH:5][CH:4]=1.[BH4-].[Na+].O.[Cl-].[NH4+]>CO>[CH3:1][O:2][C:3]1[C:11]2[O:10][CH2:9][CH:8]([OH:12])[C:7]=2[CH:6]=[CH:5][CH:4]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 25517Ammonium ChlorideHCID 28181127-Methoxybenzofuran-3(2H)-oneHCID 4311764Sodium borohydride

생성물 1

HCID 657214207-Methoxy-2,3-dihydrobenzofuran-3-ol수율 100%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a cold (ice water) solution of 7-methoxy-3-(2H)-benzofuranone (846 mg; 5.0 mmol) in methanol (5 mL) is added sodium borohydride (179 mg; 5.0 mmol) is stirred for 15 minutes. Water (5 mL) is added to the solution and stirred 15 minutes. Saturated ammonium chloride (20 mL) is added and the solution is extracted with ethyl acetate. The organics are separated and dried over magnesium sulfate. The solvent is removed to give 831 milligrams of 7-methoxy-2,3-dihydrobenzofuran-3-ol.

후처리

  1. stirringstirred 15 minutes
  2. extractionthe solution is extracted with ethyl acetate
  3. customThe organics are separated
  4. dry with materialdried over magnesium sulfate
  5. customThe solvent is removed

출처 및 근거

ORD 기록
ord-f638ed0f431b4ab7a44b77ffdd28ddb3
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07888366B2

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