Hydrochloric Acid → HCID 24777029, 화합물

HRID 1364456노트

반응식

HRID 1364456 반응식
[Sn](Cl)Cl.Cl.[F:5][C:6]1[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:7]=1[O:8][CH2:9][C:10]1[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-])=O)[C:11]=1[C:12]#[N:13].[OH-].[K+]>>[NH2:18][C:14]1[CH:15]=[CH:16][CH:17]=[C:10]([CH2:9][O:8][C:7]2[CH:21]=[CH:22][C:23]([F:25])=[CH:24][C:6]=2[F:5])[C:11]=1[C:12]#[N:13]

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 24479Stannous ChlorideHCID 24776912HCID 24776912, 화합물

생성물 1

HCID 24777029HCID 24777029, 화합물수율 91.5%

반응 조건

온도
15 °C

실험 절차

To a cooled (15° C.) and stirred solution of tin (II) chloride (0.37 g, 1.65 mmol) and con. hydrochloric acid (2.0 mL) was added a solution of 2-(2,4-difluorophenoxymethyl)-6-nitrobenzonitrile (160.0 mg, 0.55 mmol). The reaction mixture was slowly warmed to room temperature and stirred for 3 hours. The reaction mixture was poured on to crushed-ice and potassium hydroxide solution, stirred, extracted with dichloromethane, filtered and dried to yield 131 mg of 2-amino-6-(2,4-difluorophenoxymethyl)benzonitrile.

후처리

  1. temperatureThe reaction mixture was slowly warmed to room temperature
  2. additionThe reaction mixture was poured on
  3. stirringstirred
  4. extractionextracted with dichloromethane
  5. filtrationfiltered
  6. customdried

출처 및 근거

ORD 기록
ord-ab1b91f807b441d49e1d3e1813658753
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07888366B2

반응 노트

불러오는 중…