Hydrochloric Acid → HCID 22170839, 화합물
반응식
[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([CH2:12][C:13]([O:15]C)=[O:14])[CH:9]=[CH:10][CH:11]=1.[OH-].[Na+].Cl>O1CCOCC1>[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([CH2:12][C:13]([OH:15])=[O:14])[CH:9]=[CH:10][CH:11]=1참가 물질
5
실험 절차
Methyl 3-(3-chloro-propoxy)-phenylacetate (12.7 g, 52.3 mmol) was dissolved in dioxane (25 mL) and 1N NaOH (53 mL) was added. The mixture was stirred at room temperature for 45 minutes then acidified by addition of 1N hydrochloric acid (60 mL). A white precipitae formed which was filtered, washed with 1N HCl, water and dried. 3-(3-Chloro-propoxy)-phenylacetic acid (11.7 g, 98%). 1H NMR (500 MHz, CDCl3) δ 7.25 (1H, dd), 6.93–6.85 (3H, m), 4.11 (2H, t), 3.79 (2H, t), 3.70 (2H, s), 2.25 (2H, m).
후처리
- customA white precipitae formed which
- filtrationwas filtered
- washwashed with 1N HCl, water
- customdried
출처 및 근거
- ORD 기록
- ord-e5dcd26aea6a4c03a9765bb4854750e6
- 출처 데이터셋
- uspto-grants-2007_01
- 특허 번호
- US07157476B2
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