Isobutylamine → HCID 178449179, 화합물
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[NH2:1][C:2]1[C:3]([C:7]#[N:8])=[N:4][O:5][N:6]=1.[CH2:9]([NH2:13])[CH:10]([CH3:12])[CH3:11].[Al+3].[Cl-].[Cl-].[Cl-]>ClC(Cl)C>[NH2:1][C:2]1[C:3]([C:7]([NH:13][CH2:9][CH:10]([CH3:12])[CH3:11])=[NH:8])=[N:4][O:5][N:6]=1참가 물질
5
실험 절차
To a solution of 4-amino-1,2,5-oxadiazole-3-carbonitrile (220 mg, 2 mmol) and isobutylamine (0.2 mL, 2 mmol) in dichloroethane (1 mL) was added AlCl3 (293 mg, 2.2 mmol). The reaction mixture is stirred for 20 min and then quenched with ice cold water (5 mL). The mixture is extracted with diethyl ether (3×20 mL). Combined extracts was dried over anhydrous Na2SO4 and concentrated under vacuum to afford the title compound as a white solid. MS 184 M+1. The crude product was carried to next step without further purification.
후처리
- customquenched with ice cold water (5 mL)
- extractionThe mixture is extracted with diethyl ether (3×20 mL)
- dry with materialCombined extracts was dried over anhydrous Na2SO4
- concentrationconcentrated under vacuum
출처 및 근거
- ORD 기록
- ord-de97819fe603475ba62361996a85d2a3
- 출처 데이터셋
- uspto-grants-2007_01
- 특허 번호
- US07157476B2
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