Phenol → 2-Nitro-5-phenoxytoluene

HRID 1371889

반응식

HRID 1371889 반응식
[OH-].[K+].[C:3]1([OH:9])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.F[C:11]1[CH:12]=[CH:13][C:14]([N+:18]([O-:20])=[O:19])=[C:15]([CH3:17])[CH:16]=1>[OH-].[Na+]>[N+:18]([C:14]1[CH:13]=[CH:12][C:11]([O:9][C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)=[CH:16][C:15]=1[CH3:17])([O-:20])=[O:19]

참가 물질

5

반응물 3

HCID 996PhenolHCID 14797Potassium Hydroxide2회HCID 949565-Fluoro-2-nitrotoluene

생성물 1

HCID 27284182-Nitro-5-phenoxytoluene

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

Combine potassium hydroxide (3 g, 0.054 mol) and phenol (15 g, 0.16 mol), and heat to 110° C. until the potassium hydroxide is dissolved. Cool the mixture to room temperature and add 5-fluoro-2-nitrotoluene (7.75 g, 0.05 mol) in one aliquot. Heat the reaction mixture to 130° C. for 30 min, cool to room temperature, and then pour into 10% NaOH (200 mL). Extract the aqueous solution with ether (2×100 mL), combine the organic layers and wash with 10% NaOH (2×100 mL), water (2×100 mL), dry over Na2SO4 and concentrate in vacuo. Chromatograph on silica gel eluting with hexanes/ethyl acetate to give 2-nitro-5-phenoxytoluene as a solid: 1H NMR (300 MHz, CDCl3) 2.59 (s, 3H), 6.81–6.85 (m, 2H), 7.06–7.09 (m, 2H), 7.22–7.26 (m, 1H), 7.40–7.45 (m, 2H), 8.03–8.06 (m, 1H).

후처리

  1. dissolutionis dissolved
  2. temperatureHeat the reaction mixture to 130° C. for 30 min
  3. temperaturecool to room temperature
  4. extractionExtract the aqueous solution with ether (2×100 mL)
  5. washwash with 10% NaOH (2×100 mL), water (2×100 mL)
  6. dry with materialdry over Na2SO4
  7. concentrationconcentrate in vacuo

출처 및 근거

ORD 기록
ord-cfe2c1da3b894920aeb02aa9e7e9f25a
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07157488B2

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