Hydrochloric Acid → 1-(1-Methylethyl)-1H-indole-3-carboxylic acid

HRID 1372692노트

반응식

HRID 1372692 반응식
[CH:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13]([O:15]C)=[O:14])=[CH:5]1)([CH3:3])[CH3:2].[OH-].[Na+].Cl>C1COCC1>[CH:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13]([OH:15])=[O:14])=[CH:5]1)([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 10443342Methyl 1-(1-methylethyl)-1H-indole-3-carboxylate

생성물 1

HCID 103979731-(1-Methylethyl)-1H-indole-3-carboxylic acid수율 90.4%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
50 °C

실험 절차

In THF (8.0 ml) was dissolved methyl 1-isopropylindole-3-carboxylate (387.6 mg, 1.784 mmol). To the resulting solution was added 0.25N NaOH (8.0 ml). The resulting mixture was stirred at 50° C. for 18 hours. After cooling to room temperature, the reaction mixture was acidified with 1N HCl (4.5 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give 1-isopropylindole-3-carboxylic acid (327.8 mg, 90%) as a pale pink amorphous substance.

후처리

  1. temperatureAfter cooling to room temperature
  2. customThe crystals thus precipitated
  3. filtrationwere collected by filtration under reduced pressure
  4. washwashed with water
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-65d9c0157ad14ecfb548ad0e660868ee
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07157487B2

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