Sodium Hydroxide → HCID 17858998, 화합물

HRID 1372704

반응식

HRID 1372704 반응식
[Cl:1][C:2]1[C:3]([NH:15][C:16]([C:18]2[C:26]3[C:21](=[CH:22][C:23]([F:27])=[CH:24][CH:25]=3)[N:20]([CH3:28])[CH:19]=2)=[O:17])=[CH:4][C:5]([F:14])=[C:6]([CH2:8][C:9]([O:11]CC)=[O:10])[CH:7]=1.[OH-].[Na+]>C1COCC1.Cl>[Cl:1][C:2]1[C:3]([NH:15][C:16]([C:18]2[C:26]3[C:21](=[CH:22][C:23]([F:27])=[CH:24][CH:25]=3)[N:20]([CH3:28])[CH:19]=2)=[O:17])=[CH:4][C:5]([F:14])=[C:6]([CH2:8][C:9]([OH:11])=[O:10])[CH:7]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 58778583Ethyl (5-chloro-2-fluoro-4-((6-fluoro-1-methyl-3-indolylcarbonyl)amino)phenyl)acetate

생성물 1

HCID 17858998HCID 17858998, 화합물수율 97.2%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 8028Tetrahydrofuran용매

실험 절차

In THF (17 ml) was dissolved ethyl (5-chloro-2-fluoro-4-((6-fluoro-1-methyl-3-indolylcarbonyl)amino)phenyl)acetate (665 mg, 1.63 mmol). To the resulting solution was added 0.25N NaOH (9.81 ml, 2.45 mmol) and the mixture was stirred at room temperature for 14 hours. The reaction mixture was poured in 1N HCl (3.0 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water, and dried under reduced pressure to give (5-chloro-2-fluoro-4-((6-fluoro-1-methyl-3-indolylcarbonyl)amino)phenyl)acetic acid (600 mg, 97%) as a brown solid.

후처리

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration under reduced pressure
  3. washwashed with water
  4. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-06cb9ecb215940f389b5ff3fa3acb3ec
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07157487B2

연결된 노트

불러오는 중…