Water → Indazole-3-carboxylic acid
반응식
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13]([O:15]C)=[O:14])=[N:5]1)(=O)C.[OH-].[Na+].O>Cl>[NH:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13]([OH:15])=[O:14])=[N:5]1참가 물질
5
반응 조건
- 온도
- 65 °C
실험 절차
To methyl 1-acetylindazole-3-carboxylate (22.3 g, 0.10 mol) were added sodium hydroxide (8.18 g, 0.20 mol) and water (640 ml) and the resulting mixture was stirred at 60 to 70° C. for 6.5 hours. The reaction mixture was poured in concentrated HCl (30 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give indazole-3-carboxylic acid (17.6 g, 100%) as a pale yellow solid.
후처리
- customThe crystals thus precipitated
- filtrationwere collected by filtration under reduced pressure
- washwashed with water
- customdried under reduced pressure
출처 및 근거
- ORD 기록
- ord-0360e4640d5a40cf84a61038dc4d5b79
- 출처 데이터셋
- uspto-grants-2007_01
- 특허 번호
- US07157487B2
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