Sodium Hydroxide → (5-Chloro-2-fluoro-4-(3-indazolylcarbonylamino)phenyl)acetic acid

HRID 1372792노트

반응식

HRID 1372792 반응식
[Cl:1][C:2]1[C:3]([NH:15][C:16]([C:18]2[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[NH:20][N:19]=2)=[O:17])=[CH:4][C:5]([F:14])=[C:6]([CH2:8][C:9]([O:11]CC)=[O:10])[CH:7]=1.[OH-].[Na+]>CO.Cl>[Cl:1][C:2]1[C:3]([NH:15][C:16]([C:18]2[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[NH:20][N:19]=2)=[O:17])=[CH:4][C:5]([F:14])=[C:6]([CH2:8][C:9]([OH:11])=[O:10])[CH:7]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 44606313Ethyl (5-chloro-2-fluoro-4-(3-indazolylcarbonylamino)phenyl)acetate

생성물 1

HCID 17859254(5-Chloro-2-fluoro-4-(3-indazolylcarbonylamino)phenyl)acetic acid수율 98%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 887Methanol용매

실험 절차

Ethyl (5-chloro-2-fluoro-4-(3-indazolylcarbonylamino)phenyl)acetate (531 mg, 1.41 mmol) was dissolved in methanol (50 ml). To the resulting solution was added 0.25N NaOH (12 ml, 3 mmol). The resulting mixture was stirred at room temperature for 15 hours. The reaction mixture was poured in 1N HCl (100 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure for 15 hours to give (5-chloro-2-fluoro-4-(3-indazolylcarbonylamino)phenyl)acetic acid (480 mg, 98%) as a colorless crystalline powder.

후처리

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration under reduced pressure
  3. washwashed with water
  4. customdried under reduced pressure for 15 hours

출처 및 근거

ORD 기록
ord-60251fd8e08b4f8a97d74fa488b643f8
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07157487B2

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