Phosphorus oxychloride → 7-Quinazolinol, 4-chloro-5-[(tetrahydro-2H-pyran-4-yl)oxy]-, 7-acetate

HRID 1373288노트

반응식

HRID 1373288 반응식
[C:1]([O:4][C:5]1[CH:14]=[C:13]2[C:8]([C:9](=O)[NH:10][CH:11]=[N:12]2)=[C:7]([O:16][CH:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH:6]=1)(=[O:3])[CH3:2].C(N(C(C)C)CC)(C)C.P(Cl)(Cl)([Cl:34])=O>ClCCCl>[C:1]([O:4][C:5]1[CH:14]=[C:13]2[C:8]([C:9]([Cl:34])=[N:10][CH:11]=[N:12]2)=[C:7]([O:16][CH:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH:6]=1)(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 24813Phosphorus oxychlorideHCID 81531DiisopropylethylamineHCID 1355106777-(Acetyloxy)-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4(3H)-quinazolinone

생성물 1

HCID 221407987-Quinazolinol, 4-chloro-5-[(tetrahydro-2H-pyran-4-yl)oxy]-, 7-acetate

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

반응 조건

온도
80 °C

실험 절차

A mixture of 7-acetoxy-5-tetrahydropyran-4-yloxy-3,4-dihydroquinazolin-4-one (3.04 g), diisopropylethylamine (4.34 ml), phosphoryl chloride (1.02 ml) and 1,2-dichloroethane (60 ml) was stirred and heated to 80° C. for 2 hours. The mixture was evaporated to give 7-acetoxy-4-chloro-5-tetrahydropyran-4-yloxyquinazoline which was used without further purification.

후처리

  1. customThe mixture was evaporated

출처 및 근거

ORD 기록
ord-0e52511173744c54a8dbdcf96e226c28
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07160891B2

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