Diisopropylethylamine → HCID 69507675, 화합물

HRID 1374553노트

반응식

HRID 1374553 반응식
O[C:2]1C2N=NNC=2C=CC=1.C(N(C(C)C)CC)(C)C.Cl.CN(C)CCCN=C=NCC.[NH2:32][C@@H:33]1[C:39](=[O:40])[N:38]([CH:41]2[CH2:43][CH2:42]2)[C:37]2[CH:44]=[CH:45][CH:46]=[CH:47][C:36]=2[N:35]([CH3:48])[CH2:34]1.[C:49]([OH:54])(=O)[C@H:50]([CH3:52])[OH:51]>C1COCC1>[CH:43]1([CH2:41][N:38]2[C:39](=[O:40])[C@@H:33]([NH:32][C:49](=[O:54])[C@@H:50]([OH:51])[CH3:52])[CH2:34][N:35]([CH3:48])[C:36]3[CH:47]=[CH:46][CH:45]=[CH:44][C:37]2=3)[CH2:42][CH2:2]1

참가 물질

7

반응물 5

HCID 81531DiisopropylethylamineHCID 107689L-Lactic AcidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 69507494HCID 69507494, 화합물HCID 178418300HCID 178418300, 화합물

생성물 1

HCID 69507675HCID 69507675, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Hydroxybenzotriazole (121 mg, 1 mmol), diisopropylethylamine (23 2 mg, 2 mmol) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (172 mg, 1 mmol) were added to a cooled (0° C.) solution of (S)-3-amino-1-cyclopropyl-5-methyl-1,3,4,5-tetrahydro-benzo[b][1,4]diazepin-2-one (220 mg, 1 mmol) and L-(+)-lactic acid (81 mg, 1 mmol) in THF (2 ml) and stirred overnight at r.t. The solvent was evaporated, the residue was taken up in dichloromethane and washed with water. The organic phase was dried over Na2SO4 and evaporated. Upon chromatographic purification (silica gel, dichloromethane/methanol=1:0−9:1) the title compound (347 mg, quant.) was obtained as a white solid.

후처리

  1. customThe solvent was evaporated
  2. washwashed with water
  3. dry with materialThe organic phase was dried over Na2SO4
  4. customevaporated
  5. customUpon chromatographic purification (silica gel, dichloromethane/methanol=1:0−9:1) the title compound (347 mg, quant.)
  6. customwas obtained as a white solid

출처 및 근거

ORD 기록
ord-cc22f71021d94a0cbed3c6cbbbe8695b
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07166587B2

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