Sodium Iodide → [2-(4-Acetylamino-phenyl)-1,3-dioxo-indan-2-yl]-acetic acid ethyl ester

HRID 1375082

반응식

HRID 1375082 반응식
[Na].[C:2]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([CH:12]2[C:20](=[O:21])[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]2=[O:22])=[CH:8][CH:7]=1)(=[O:4])[CH3:3].[I-].[Na+].[CH2:25]([O:27][C:28](=[O:31])[CH2:29]Cl)[CH3:26]>C(O)C.O>[CH2:25]([O:27][C:28](=[O:31])[CH2:29][C:12]1([C:9]2[CH:8]=[CH:7][C:6]([NH:5][C:2](=[O:4])[CH3:3])=[CH:11][CH:10]=2)[C:20](=[O:21])[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:13]1=[O:22])[CH3:26]

참가 물질

7

반응물 4

HCID 5238Sodium IodideHCID 7751Ethyl chloroacetateHCID 853463N-[4-(1,3-Dioxo-indan-2-yl)-phenyl]-acetamideHCID 5360545Sodium

생성물 1

HCID 12776985[2-(4-Acetylamino-phenyl)-1,3-dioxo-indan-2-yl]-acetic acid ethyl ester

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

A solution of sodium (0.412 g) in absolute ethanol ((200 mL) was treated with 2-(4-acetylaminophenyl)-indan-1,3-dione (5 g, Reference Example 14) then with sodium iodide (2.69 g) and chloroacetic acid ethyl ester (3.6 mL). The mixture was heated at 100° C. for 20 minutes then poured into water (500 mL) and then extracted with ethyl acetate (500 mL). The organic extract was dried over magnesium sulfate and then evaporated to give the title compound (5.25 g) as a pale coloured solid.

후처리

  1. extractionextracted with ethyl acetate (500 mL)
  2. extractionThe organic extract
  3. dry with materialwas dried over magnesium sulfate
  4. customevaporated

출처 및 근거

ORD 기록
ord-1d706fade44a46c7a9e5e7913c1aa4b0
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07166616B2

연결된 노트

불러오는 중…