Hydrochloric Acid → 3-Ethylpent-2-enoic acid

HRID 1375936

반응식

HRID 1375936 반응식
C[O:2][C:3](=[O:10])[CH:4]=[C:5]([CH2:8][CH3:9])[CH2:6][CH3:7].[OH-].[Na+].Cl>O1CCOCC1>[CH2:6]([C:5]([CH2:8][CH3:9])=[CH:4][C:3]([OH:10])=[O:2])[CH3:7]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 588380Methyl 3-ethylpent-2-enoate

생성물 1

HCID 127483593-Ethylpent-2-enoic acid수율 90.3%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

3-ethyl pent-2-enoic acid methyl ester (200 mg, 1.4 mmol) was dissolved in dioxane (1 ml). 1N NaOH (1 ml) was added, and the mixture was left overnight at 50° C.; 1N hydrochloric acid was added (2 ml), and the compound was extracted with ethyl acetate. The organic solution was dried over sodium sulfate, filtered and the solvent was removed under reduced pressure, obtaining 162 mg of 3-ethylpent-2-enoic acid as colourless oil. Yield 90%. 1H-NMR: (CDCl3, 500 MHz) chemical shift p.p.m. 1.06–1.11 (m, 6H, CH2CH3); 2.23 (q, 2H, CH3CH2); 2.64 (q, 2H, CH3CH2); 5.65 (s, 1H, CHC(O)).

후처리

  1. extractionthe compound was extracted with ethyl acetate
  2. dry with materialThe organic solution was dried over sodium sulfate
  3. filtrationfiltered
  4. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-2d9251327f894ff59cd3072e9db18bc0
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07169890B2

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