Pyridine → 1-Methoxypropan-2-yl chloroformate

1 ml (10.2 mmol) of 1-methoxy-2-propanol (Fluka, Buchs, Switzerland) is injected slowly into an ice-cold solution of 916 mg (1.1 equivalent) of bis(trichloromethyl) carbonate (triphosgene; Fluka, Buchs, Switzerland) in 35 ml of ether using a syringe. At the same time, 1 ml (1.2 equivalents) of pyridine in 5 ml of ether is added dropwise from a dropping funnel. After the addition has ended, the mixture is left to stir at RT for a further 60 min. The reaction mixture is filtered through wadding and the solvent is carefully evaporated off (35° C. waterbath). The oily residue (title compound) is subjected to further processing without any purification. 1H-NMR (200 MHz; CDCl3)=inter alia 5.05/m (1H); 3.30/s (3H); 1.27/d (3H).

1. additionAfter the addition
2. waitthe mixture is left
3. filtrationThe reaction mixture is filtered through wadding
4. customthe solvent is carefully evaporated off (35° C. waterbath)
5. customThe oily residue (title compound) is subjected to further processing without any purification

ORD 기록

ord-e99c8e57c0134604afd99b521c687814

출처 데이터셋

uspto-grants-1997_09

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US05663200