Ethanol → 3-(Difluoromethoxy)benzaldehyde Oxime

HRID 1380047노트

반응식

HRID 1380047 반응식
Cl.[NH2:2][OH:3].[OH-].[Na+].[F:6][CH:7]([F:17])[O:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=1)[CH:12]=O.C(O)C>O>[F:6][CH:7]([F:17])[O:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=1)[CH:12]=[N:2][OH:3]

참가 물질

6

반응물 4

HCID 702EthanolHCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 27369853-(Difluoromethoxy)benzaldehyde

생성물 1

HCID 861304583-(Difluoromethoxy)benzaldehyde Oxime

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A 2.0 g portion of hydroxylamine hydrochloride was dissolved in 12 ml of water and 8 ml of 5N sodium hydroxide was added. A 1.0 g portion of 3-(difluoromethoxy)benzaldehyde was added followed by enough ethanol to give a solution. After 10 minutes of reflux, the reaction mixture was concentrated in vacuo and the residue taken up in 10 ml of water. The pH was adjusted to 4 with hydrochloric acid, then the mixture was extracted with chloroform. The organic phase was dried over sodium sulfate and concentrated, giving the desired compound as an oil.

후처리

  1. customto give a solution
  2. temperatureAfter 10 minutes of reflux
  3. concentrationthe reaction mixture was concentrated in vacuo
  4. extractionthe mixture was extracted with chloroform
  5. dry with materialThe organic phase was dried over sodium sulfate
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-dc009ea92b184a389b33de1a2d438e19
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04579848

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