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Hydrochloric Acid → (E)-1-(4-Chloro-1-butenyl)-4-fluorobenzene

HRID 1380343
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반응식

HRID 1380343 반응식
[CH:1]1([CH:4]([C:6]2[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=2)O)[CH2:3][CH2:2]1.[ClH:13]>C(Cl)(Cl)Cl>[Cl:13][CH2:3][CH2:2]/[CH:1]=[CH:4]/[C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 102498alpha-Cyclopropyl-4-fluorobenzenemethanol

생성물 1

HCID 20188301(E)-1-(4-Chloro-1-butenyl)-4-fluorobenzene

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Dissolve 12.8 g (0.077 mole) of α-cyclopropyl-4-fluorobenzenemethanol in 60 ml of CHCl3, add 20 ml of concentrated HCl and reflux overnight. Separate the two layers, and extract the aqueous layer with methylene chloride. Combine the methylene chloride extracts with the chloroform layer and wash with saturated aqueous sodium bicarbonate, and dry over magnesium sulfate. Evaporate the organic solvents to yield the title compound.

후처리

  1. temperaturereflux overnight
  2. customSeparate the two layers
  3. extractionextract the aqueous layer with methylene chloride
  4. washwash with saturated aqueous sodium bicarbonate
  5. dry with materialdry over magnesium sulfate
  6. customEvaporate the organic solvents

출처 및 근거

ORD 기록
ord-bb0df537d11548a2b4de398c8f1318fc
출처 데이터셋
uspto-grants-1986_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04581370

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