2,3-Diaminopyridine → HCID 178493630, 화합물

HRID 1380719

반응식

HRID 1380719 반응식
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([S:12]([Cl:15])(=[O:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5](O)=O.[NH2:16]C1C=CC(C(O)=O)=C(OC)C=1.N[C:29]1[C:34]([NH2:35])=[CH:33][CH:32]=[CH:31][N:30]=1>P(Cl)(Cl)(Cl)=O>[ClH:15].[CH3:1][O:2][C:3]1[CH:11]=[C:10]([S:12]([Cl:15])(=[O:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5]1[NH:16][C:33]2=[CH:32][CH:31]=[N:30][CH:29]=[C:34]2[N:35]=1

참가 물질

5

반응물 3

HCID 99562,3-DiaminopyridineHCID 755994-Amino-o-anisic acidHCID 201845804-(Chlorosulfonyl)-2-methoxybenzoic acid

생성물 1

HCID 178493630HCID 178493630, 화합물

시약·촉매·용매 1

HCID 24813Phosphorus oxychloride용매

반응 조건

온도
80 °C

실험 절차

Five grams of 2-methoxy-4-chlorosulfonyl-benzoic acid (prepared from 4-amino-2-methoxy-benzoic acid via the corresponding diazonium compound) were dissolved in 400 ml of phosphorus oxychloride and heated to 80° C. for 30 minutes. Then, 3.6 gm of 2,3-diaminopyridine were added, and the mixture was refluxed for four hours. The reaction mixture was concentrated by evaporation in vacuo and re-evaporated with toluene, and the solid residue was processed further without any other purification.

후처리

  1. temperaturethe mixture was refluxed for four hours
  2. concentrationThe reaction mixture was concentrated by evaporation in vacuo
  3. customre-evaporated with toluene
  4. customthe solid residue was processed further without any other purification

출처 및 근거

ORD 기록
ord-94633bad767d4d8fbfd17521349fbbb8
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04582837

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