Hydrochloric Acid → 3-Methoxy-4-(7H-purin-8-yl)benzamide
반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]#[N:10])[CH:6]=[CH:5][C:4]=1[C:11]1[NH:19][C:18]2[C:13](=[N:14][CH:15]=[N:16][CH:17]=2)[N:12]=1.Cl.[OH-:21].[Na+]>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]([NH2:10])=[O:21])[CH:6]=[CH:5][C:4]=1[C:11]1[NH:19][C:18]2[C:13](=[N:14][CH:15]=[N:16][CH:17]=2)[N:12]=1참가 물질
4
실험 절차
One gram of 8-(2'-methoxy-4'-cyano-phenyl)-purine was dissolved in 75 ml of 2N sodium hydroxide solution and refluxed for 15 minutes. Then, the mixture was acidified with hydrochloric acid, and the mixture precipitated was separated into its components by use of silica gel [eluant: methylene chloride/ethanol (7:3 to 1:1)].
후처리
- temperaturerefluxed for 15 minutes
- customthe mixture precipitated
- customwas separated into its components by use of silica gel [eluant: methylene chloride/ethanol (7:3 to 1:1)]
출처 및 근거
- ORD 기록
- ord-cb128f2b04994f23a022483e480031f5
- 출처 데이터셋
- uspto-grants-1986_04
- 특허 번호
- US04582837
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