Hydrochloric Acid → 4-Nitro-3-(4-methoxyphenyl)heptanedioic acid dimethyl ester

HRID 1380949노트

반응식

HRID 1380949 반응식
[CH3:1][O:2][C:3](=[O:18])[CH2:4][CH:5]([C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1)[CH2:6][N+:7]([O-:9])=[O:8].[C:19]([O:23][CH3:24])(=[O:22])[CH:20]=[CH2:21].Cl>C(O)(C)(C)C.C(OCC)C>[CH3:1][O:2][C:3](=[O:18])[CH2:4][CH:5]([C:10]1[CH:11]=[CH:12][C:13]([O:16][CH3:17])=[CH:14][CH:15]=1)[CH:6]([N+:7]([O-:9])=[O:8])[CH2:21][CH2:20][C:19]([O:23][CH3:24])=[O:22]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 7294Methyl AcrylateHCID 54303925Methyl 3-(4-methoxyphenyl)-4-nitrobutanoate

생성물 1

HCID 537595764-Nitro-3-(4-methoxyphenyl)heptanedioic acid dimethyl ester

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6386tert-Butanol용매

실험 절차

A solution of 200 g of 4-nitro-3-(4-methoxyphenyl)butanoic acid methyl ester, 68 g of methyl acrylate, and 25 ml of Triton B in 500 ml of t-butanol is allowed to stir at room temperature for 94 hours. Excess aqueous hydrochloric acid (1 N) is added and the solution is diluted with diethyl ether. The organic layer is separated, dried over anhydrous magnesium sulfate, and evaporated to give 4-nitro-3-(4-methoxyphenyl)heptanedioic acid dimethyl ester.

후처리

  1. customThe organic layer is separated
  2. dry with materialdried over anhydrous magnesium sulfate
  3. customevaporated

출처 및 근거

ORD 기록
ord-19200836ea4046b3b41791521a3b5c92
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04584313

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