Water → HCID 14838486, 화합물
반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][C:10]1[CH:14]=[CH:13][NH:12][N:11]=1.[OH-].[K+].[CH3:17]I.O>CS(C)=O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][C:10]1[CH:14]=[CH:13][N:12]([CH3:17])[N:11]=1참가 물질
6
실험 절차
The pyrazole from Example 5 (b) (4.0 g) was added to a mixture of crushed potassium hydroxide pellets (4.7 g) in dry dimethylsulphoxide, which had previously been stirred for 5 minutes under nitrogen at room temperature. After stirring for 0.75 hours, methyl iodide (3.1 g) was added to the red solution and stirring was maintained for a further 0.75 hours. The reaction mix was poured into water, extracted with ethyl acetate, the organic layer washed, dried, evaporated and chromatographed to give a light brown oil.
후처리
- stirringAfter stirring for 0.75 hours
- stirringstirring
- temperaturewas maintained for a further 0.75 hours
- additionThe reaction mix
- extractionextracted with ethyl acetate
- washthe organic layer washed
- customdried
- customevaporated
- customchromatographed
- customto give a light brown oil
출처 및 근거
- ORD 기록
- ord-27a3ed433f4542ce95aeb5a1af5b534f
- 출처 데이터셋
- uspto-grants-1989_02
- 특허 번호
- US04803216
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