Methyl bromoacetate → HCID 14402229, 화합물

HRID 1382183노트

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HRID 1382183 반응식
Br[CH2:2][C:3]([O:5][CH3:6])=[O:4].[CH2:7]([NH:9][C:10]1[CH:11]=[C:12]([OH:16])[CH:13]=[CH:14][CH:15]=1)[CH3:8].C(N(C(C)C)C(C)C)C>C1(C)C=CC=CC=1>[CH3:6][O:5][C:3](=[O:4])[CH2:2][N:9]([CH2:7][CH3:8])[C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([OH:16])[CH:11]=1

참가 물질

5

반응물 3

HCID 60984Methyl bromoacetateHCID 81531DiisopropylethylamineHCID 5789913-Ethylaminophenol

생성물 1

HCID 14402229HCID 14402229, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
100 °C

실험 절차

Methyl bromoacetate (10.7 g, 70 mmole), 3-(ethylamino) phenol from above (4.8 g, 35 mmole), and ethyl diisopropyl amine (4.45 g, 35 mmole) were combined in 25 ml of toluene. The mixture was heated at 100° C. for 30 min. and then evaporated under vacuum and chromatographed on a silica gel column using 5% (v/v) methanol/methylene chloride. The combined fractions were washed with saturated sodium bicarbonate and neutralized with 0.1N HCL. The combined fractions were dried over Na2SO4 and evaporated to give 7.24 g of N-ethyl-N-3-hydroxyphenyl glycine methyl ester.

후처리

  1. customevaporated under vacuum
  2. customchromatographed on a silica gel column
  3. washThe combined fractions were washed with saturated sodium bicarbonate and neutralized with 0.1N HCL
  4. dry with materialThe combined fractions were dried over Na2SO4
  5. customevaporated

출처 및 근거

ORD 기록
ord-ccf382539ac54e4c9c90bea6fd1e7c0a
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04806488

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