1-Phenylpiperazine → 1-Phenoxy-4-(4-phenyl-1-piperazinyl)-2-butanol

HRID 1382397노트

반응식

HRID 1382397 반응식
[C:1]1([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[CH2:14][CH2:15][CH:16]([OH:25])[CH2:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)CCC>[O:18]([CH2:17][CH:16]([OH:25])[CH2:15][CH2:14][N:10]1[CH2:11][CH2:12][N:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:8][CH2:9]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

참가 물질

5

반응물 3

HCID 70961-PhenylpiperazineHCID 10340Sodium CarbonateHCID 131203424-Chloro1-phenoxy-2-butanol

생성물 1

HCID 144229031-Phenoxy-4-(4-phenyl-1-piperazinyl)-2-butanol

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

A mixture of 6.5 g (0.04 mole) of 1-phenylpiperazine, 8.4 g (0.042 mole) of 4-chloro-1-phenoxy-2-butanol and 15.9 g (0.15 mole) of anhydrous sodium carbonate in 200 ml of 1-butanol was heated at reflux 20 hr. The mixture was concentrated under reduced pressure and the residue was partitioned between water and benzene. The benzene layer was washed with water and aqueous saturated sodium chloride solution, dried over sodium sulfate and concentrated under reduced pressure to give the title product in the residue which was recrystallized from isopropyl alcohol to give 8.9 g (68%) of white powder, m.p. 93°-94° C.

후처리

  1. temperaturewas heated
  2. temperatureat reflux 20 hr
  3. concentrationThe mixture was concentrated under reduced pressure
  4. customthe residue was partitioned between water and benzene
  5. washThe benzene layer was washed with water and aqueous saturated sodium chloride solution
  6. dry with materialdried over sodium sulfate
  7. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-303220ce004d4fad8b1340743f36b87e
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04806555

반응 노트

불러오는 중…