Hydrochloric Acid → HCID 21186672, 화합물

HRID 1384264노트

반응식

HRID 1384264 반응식
[CH3:1][C:2]1[N:7]=[C:6]2[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:5]2=[CH:4][C:3]=1[C:13]([O:15]CC)=[O:14].Cl>[OH-].[Na+]>[CH3:1][C:2]1[N:7]=[C:6]2[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:5]2=[CH:4][C:3]=1[C:13]([OH:15])=[O:14]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 21186750HCID 21186750, 화합물

생성물 1

HCID 21186672HCID 21186672, 화합물수율 72.7%

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

Ethyl 2-methyl-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine-3-carboxylate (3.05 g, 13.1 mmol) was suspended in 5% sodium hydroxide aqueous solution (20.0 ml) and heated under reflux for 1 hour. After cooling to room temperature, this was adjusted to pH 4 by adding concentrated hydrochloric acid and extracted with chloroform-methanol (4:1) mixed solvent. The thus obtained organic layer was washed with saturated brine and then dried over anhydrous sodium sulfate. By evaporating the solvent under reduced pressure, the title compound (1.95 g, 72.7%) was obtained as pale brown powder.

후처리

  1. temperatureheated
  2. temperatureunder reflux for 1 hour
  3. extractionextracted with chloroform-methanol (4:1)
  4. additionmixed solvent
  5. washThe thus obtained organic layer was washed with saturated brine
  6. dry with materialdried over anhydrous sodium sulfate
  7. customBy evaporating the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-76ceae29ce494296ab4dbf8d8c16e20a
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06258829B1

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