Hydrochloric Acid → 2,2-dibromo-1-methylcyclopropanecarboxylic acid

HRID 1385182노트

반응식

HRID 1385182 반응식
[Br:1][C:2]1([Br:10])[CH2:4][C:3]1([CH3:9])[C:5]([O:7]C)=[O:6].[OH-].[Li+].Cl>O1CCCC1.O>[Br:1][C:2]1([Br:10])[CH2:4][C:3]1([CH3:9])[C:5]([OH:7])=[O:6]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 363499339647-01-3

생성물 1

HCID 27580372,2-dibromo-1-methylcyclopropanecarboxylic acid수율 620.4%

시약·촉매·용매 1

HCID 21881883Oxolane--water (1/1)용매

실험 절차

To 25 mL of a 50:50 mixture of tetrahydrofuran/water was added 2,2-dibromo-1-methylcyclopropanecarboxylic acid, methyl ester(2.72 g, 10 mmol)and lithium hydroxide (0.8 g, 20 mmol). The reaction mixture was stirred overnight. The reaction mixture was acidified with 1 M hydrochloric acid (24 mL). The reaction mixture was extracted with dichloromethane (2×25 mL) and the organic phases were collected, washed with brine, dried (MgSO4)and evaporated to give the title product (16 g) as white crystals mp 108-109° C.

후처리

  1. extractionThe reaction mixture was extracted with dichloromethane (2×25 mL)
  2. customthe organic phases were collected
  3. washwashed with brine, dried (MgSO4)and
  4. customevaporated

출처 및 근거

ORD 기록
ord-7520ee281714406bb0cc9ab783c962e9
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06262099B1

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