Sodium borohydride → 6-Ethoxytetralin-2-ol

HRID 1385892

반응식

HRID 1385892 반응식
[BH4-].[Na+].[CH2:3]([O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[CH2:12][C:11](=[O:16])[CH2:10][CH2:9]2)[CH3:4]>C(O)C.[OH-].[Na+]>[CH2:3]([O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[CH2:12][CH:11]([OH:16])[CH2:10][CH2:9]2)[CH3:4]

참가 물질

5

반응물 2

HCID 4311764Sodium borohydrideHCID 46940316-Ethoxy-2-tetralone

생성물 1

HCID 118302726-Ethoxytetralin-2-ol

시약·촉매·용매 2

HCID 702Ethanol용매HCID 14798Sodium Hydroxide용매

반응 조건

온도
0 °C

실험 절차

1.97 g (52 mmol) of sodium borohydride were added in portions of 0° C. to 9.8 g (51.4 mmol) of 6-ethoxy-2-tetralone in 150 ml of ethanol. The mixture was stirred for 1 hour at 0° C. and diluted with 200 ml of 2N sodium hydroxide solution, and the solution was extracted with dichloromethane. The combined organic phases were washed with saturated sodium chloride solution, dried and concentrated. This gave 9.8 g of an oil which was further reacted without purification.

후처리

  1. extractionthe solution was extracted with dichloromethane
  2. washThe combined organic phases were washed with saturated sodium chloride solution
  3. customdried
  4. concentrationconcentrated
  5. customThis gave 9.8 g of an oil which was further reacted without purification

출처 및 근거

ORD 기록
ord-39e1cd72b30b4ec9b1d6e51fdb92caea
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06265398B1

연결된 노트

불러오는 중…