Hydrochloric Acid → Benzoate hydrochloride

HRID 1386623노트

반응식

HRID 1386623 반응식
BrCCCCCCCCOC1C=CC([C:17]2[CH:25]=[CH:24][C:20]([C:21]([OH:23])=[O:22])=[CH:19][CH:18]=2)=CC=1.O.C(OCC)(=O)C.[ClH:33]>CC1OC(C)CNC1>[ClH:33].[C:21]([OH:23])(=[O:22])[C:20]1[CH:24]=[CH:25][CH:17]=[CH:18][CH:19]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 8857Ethyl AcetateHCID 211822604-[4-(8-Bromooctyloxy)phenyl]benzoic acid

생성물 1

HCID 57447319Benzoate hydrochloride

시약·촉매·용매 1

HCID 1108622,6-Dimethylmorpholine용매

실험 절차

A suspension of 4-[4-(8-bromooctyloxy)phenyl]benzoic acid (1 g) in 2,6-dimethylmorpholine (3.06 ml) was refluxed for 30 minutes. The reaction mixture was added to mixture of water and ethyl acetate and adjusted to pH 2.0 with conc. HCl. The organic layer was taken and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 4-[4-[8-2,6-dimethylmorpholin-4-yl)octyloxy]phenyl]benzoic acid hydrochloride (0.95 g).

후처리

  1. temperaturewas refluxed for 30 minutes
  2. dry with materialdried over magnesium sulfate
  3. filtrationThe magnesium sulfate was filtered off
  4. customthe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-0c47cfe300914c43b9fd4ae074fea63e
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06265536B1

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