Hydrochloric Acid → 2-(R)-(3-(S)-((4-(3-(4-Fluorophenyl)propyl)-4-hydroxy-piperidin-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid

HRID 1386757

반응식

HRID 1386757 반응식
[CH:1]([C@@H:3]1[C@@H:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:6][N:5]([C@H:14]([CH:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)[C:15]([O:17]CC2C=CC=CC=2)=[O:16])[CH2:4]1)=O.[OH:31][C:32]1([CH2:38][CH2:39][CH2:40][C:41]2[CH:46]=[CH:45][C:44]([F:47])=[CH:43][CH:42]=2)[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1.Cl>>[F:47][C:44]1[CH:43]=[CH:42][C:41]([CH2:40][CH2:39][CH2:38][C:32]2([OH:31])[CH2:33][CH2:34][N:35]([CH2:1][C@@H:3]3[C@@H:7]([C:8]4[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=4)[CH2:6][N:5]([C@H:14]([CH:25]4[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]4)[C:15]([OH:17])=[O:16])[CH2:4]3)[CH2:36][CH2:37]2)=[CH:46][CH:45]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 183648764-[3-(4-Fluorophenyl)propyl]piperidin-4-olHCID 599246172-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid, benzyl ester

생성물 1

HCID 206723732-(R)-(3-(S)-((4-(3-(4-Fluorophenyl)propyl)-4-hydroxy-piperidin-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid

실험 절차

The title compound was prepared from 2-(R)-(3-(R)-Formyl-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid, benzyl ester (from EXAMPLE 1, Step I) and 4-hydroxy-4-(3-(4-fluorophenyl)propyl) piperidine.HCl (from EXAMPLE 110, Step A) using procedures analogous to those described in EXAMPLE 1, Steps J and K. For the title compound: ESI-MS 537 (M+H).

출처 및 근거

ORD 기록
ord-7b91175471fc491080b14c28e972e1a3
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06265434B1

연결된 노트

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