Diazomethane → Ethyl 4-methoxy-3-ethoxycarbonyl-1-methylpyrrole-2-acetate

HRID 1388930

반응식

HRID 1388930 반응식
[OH:1][C:2]1[C:3]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[C:4]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[N:5]([CH3:7])[CH:6]=1.[N+](=[CH2:21])=[N-].CN(N=O)C(N)=O.[OH-].[K+]>C(OCC)C>[CH3:21][O:1][C:2]1[C:3]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[C:4]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[N:5]([CH3:7])[CH:6]=1

참가 물질

6

반응물 4

HCID 9550DiazomethaneHCID 12699N-Methyl-N-nitrosoureaHCID 14797Potassium HydroxideHCID 13345719Ethyl 3-ethoxycarbonyl-4-hydroxy-1-methylpyrrole-2-acetate

생성물 1

HCID 20469092Ethyl 4-methoxy-3-ethoxycarbonyl-1-methylpyrrole-2-acetate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Ethyl 4-hydroxy-3-ethoxycarbonyl-1-methylpyrrole-2-acetate (20 mmole) is dissolved in 10 μl of diethyl ether containing diazomethane freshly prepared from N-methyl-N-nitrosourea and potassium hydroxide. After the reaction is allowed to stand at room temperature for about 0.5 hour, the ether is evaporated under reduced pressure at mild temperature and the residue, i.e., crude ethyl-4-methoxy-3-ethoxycarbonyl-1-methylpyrrole-2-acetate, is used in the next step without further purification.

후처리

  1. customthe ether is evaporated under reduced pressure at mild temperature
  2. customthe residue, i.e., crude ethyl-4-methoxy-3-ethoxycarbonyl-1-methylpyrrole-2-acetate, is used in the next step without further purification

출처 및 근거

ORD 기록
ord-195bafe7bb434b3881f51fa3bf30cad8
출처 데이터셋
uspto-grants-1984_02
특허 번호
US04434175

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