Methyl iodide → 2,2-Dimethylhexanenitrile

HRID 1389174

반응식

HRID 1389174 반응식
[CH3:1][C:2]([CH3:9])([CH2:5][CH2:6][CH2:7][CH3:8])[CH2:3][NH2:4].C(#N)CCCCC.CI.[NH2-].[Na+]>O.C1(C)C=CC=CC=1>[CH3:1][C:2]([CH3:9])([CH2:5][CH2:6][CH2:7][CH3:8])[C:3]#[N:4]

참가 물질

7

반응물 4

HCID 6328Methyl iodideHCID 12352HexanenitrileHCID 24533Sodium amideHCID 543253312,2-Dimethylhexan-1-amine

생성물 1

HCID 35735622,2-Dimethylhexanenitrile수율 81%

시약·촉매·용매 2

HCID 962Water용매HCID 1140Toluene용매2회

실험 절차

2,2-Dimethylhex-1-ylamine. A solution of capronitrile (25 g., 0.26 mole) and methyl iodide (75 g., 0.53 mole) in 80 ml. of dry toluene is warmed to 80° and treated gradually with a suspension of sodium amide (25.4 g., 0.65 mole) in 100 ml. of toluene at a rate sufficient to maintain general reflux. After addition is complete, the mixture is stirred and refluxed for an additional 2 hr. period, cooled and treated with 150 ml. of water. The organic layer is separated, washed with water and dried over magnesium sulfate. Concentration of the dried solution under reduced pressure and distillation of residual material affords an 81% yield of 2,2-dimethylcapronitrile.

후처리

  1. temperaturereflux
  2. additionAfter addition
  3. temperaturerefluxed for an additional 2 hr
  4. temperatureperiod, cooled
  5. additiontreated with 150 ml
  6. customThe organic layer is separated
  7. washwashed with water
  8. dry with materialdried over magnesium sulfate
  9. distillationConcentration of the dried solution under reduced pressure and distillation of residual material

출처 및 근거

ORD 기록
ord-b10eaa5a65e849c58391f3ae0f7ee78e
출처 데이터셋
uspto-grants-1981_01
특허 번호
US04243681

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