Isobutyryl chloride → Flutamide
반응식
[N+:1]([C:4]1[CH:10]=[CH:9][C:7]([NH2:8])=[CH:6][C:5]=1[C:11]([F:14])([F:13])[F:12])([O-:3])=[O:2].[C:15](Cl)(=[O:19])[CH:16]([CH3:18])[CH3:17]>N1C=CC=CC=1>[N+:1]([C:4]1[CH:10]=[CH:9][C:7]([NH:8][C:15](=[O:19])[CH:16]([CH3:18])[CH3:17])=[CH:6][C:5]=1[C:11]([F:12])([F:13])[F:14])([O-:3])=[O:2]참가 물질
4
실험 절차
To a stirred, cooled solution of 100 g. of 4-nitro-3-trifluoromethylaniline in 400 ml. of pyridine, slowly and in a dropwise fashion, add 54 g. of isobutyrylchloride and then heat the reaction mixture on a steam bath for 1.5 hours. Cool and pour the resulting mixture into ice-water, filter and water-wash the crude anilide, crystallize the product of this example from benzene to obtain analytically pure material, m.p. 111.5°-112.5° C.
후처리
- temperatureTo a stirred, cooled solution of 100 g
- temperatureCool
- filtrationfilter
- washwater-wash the crude anilide
- customcrystallize the product of this example from benzene
- customto obtain analytically pure material, m.p. 111.5°-112.5° C.
출처 및 근거
- ORD 기록
- ord-06fde731beeb4845b165fe0d5c019f3b
- 출처 데이터셋
- uspto-grants-1979_02
- 특허 번호
- US04139638
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