Methanethiol → 3-(4-Methoxybenzylmercapto)-2-(methylthio)propanoic acid

HRID 1391091

반응식

HRID 1391091 반응식
Br[CH:2]([CH2:6][S:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=1)[C:3]([OH:5])=[O:4].[CH3:17][SH:18].[OH-].[Na+]>C(O)C>[CH3:16][O:15][C:12]1[CH:13]=[CH:14][C:9]([CH2:8][S:7][CH2:6][CH:2]([S:18][CH3:17])[C:3]([OH:5])=[O:4])=[CH:10][CH:11]=1

참가 물질

5

반응물 3

HCID 878MethanethiolHCID 14798Sodium HydroxideHCID 203852902-Bromo-3-(4-methoxybenzylmercapto)propanoic acid

생성물 1

HCID 540570183-(4-Methoxybenzylmercapto)-2-(methylthio)propanoic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 2-bromo-3-(4-methoxybenzylmercapto)propanoic acid (15 g.), methylmercaptan (3 g.) and sodium hydroxide (4.6 g.) in 95% ethanol (25 ml.) is refluxed for twelve hours. The sodium bromide is filtered off and the filtrate is concentrated to dryness in vacuo. The residue is dissolved in water, acidified with concentrated hydrochloric acid and extracted with ethyl acetate. The organic layer is dried and concentrated to dryness to yield 3-(4-methoxybenzylmercapto)-2-(methythio)propanoic acid.

후처리

  1. filtrationThe sodium bromide is filtered off
  2. concentrationthe filtrate is concentrated to dryness in vacuo
  3. dissolutionThe residue is dissolved in water
  4. extractionextracted with ethyl acetate
  5. customThe organic layer is dried
  6. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-ba37de8ceaa246fa9770dd2df872a9d3
출처 데이터셋
uspto-grants-1979_02
특허 번호
US04140864

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