Hydrochloric Acid → HCID 69315002, 화합물

HRID 1391713노트

반응식

HRID 1391713 반응식
[Li+].[OH-].O.[C:4]([NH:7][C@:8]1([CH:22]([CH2:24][CH3:25])[CH3:23])[CH2:12][CH2:11][N:10]([C@@H:13]([CH2:18][CH:19]=[CH2:20])[C:14]([O:16]C)=[O:15])[C:9]1=[O:21])(=[O:6])[CH3:5].Cl>C1COCC1>[C:4]([NH:7][C@:8]1([CH:22]([CH2:24][CH3:25])[CH3:23])[CH2:12][CH2:11][N:10]([C@@H:13]([CH2:18][CH:19]=[CH2:20])[C:14]([OH:16])=[O:15])[C:9]1=[O:21])(=[O:6])[CH3:5]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 69316592(s)-Methyl 2-((s)-3-acetamido-3-sec-butyl-2-oxopyrrolidin-1-yl)pent-4-enoate

생성물 1

HCID 69315002HCID 69315002, 화합물수율 88.2%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Step L (7): A solution of LiOH/H2O (2M, 28 mg in 0.50 mL) was added to the diastereomer B, (S)-methyl 2-((S)-3-acetamido-3-sec-butyl-2-oxopyrrolidin-1-yl)pent-4-enoate (122 mg, 0.39 mmol) from Step L (6) in THF (1.0 mL) at RT. The reaction was stirred for 3 days. The mixture was poured into 1N HCl and the aqueous layer was extracted with EtOAC. The combined organic layers were washed with brine, dried over NaSO4 and concentrated in vacuo to give 102 mg of the title compound as white solid. LC-MS (M+H)+=297.01.

후처리

  1. extractionthe aqueous layer was extracted with EtOAC
  2. washThe combined organic layers were washed with brine
  3. dry with materialdried over NaSO4
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-99cbc239ed154870975f576a4d3ff0b8
출처 데이터셋
uspto-grants-2008_03
특허 번호
US07338974B2

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