Hydrochloric Acid → 2-[(4-Acetylphenyl)sulfanyl]acetic acid
반응식
C[O:2][C:3](=[O:15])[CH2:4][S:5][C:6]1[CH:11]=[CH:10][C:9]([C:12](=[O:14])[CH3:13])=[CH:8][CH:7]=1.[Li+].[OH-].Cl>C1COCC1.O>[C:12]([C:9]1[CH:8]=[CH:7][C:6]([S:5][CH2:4][C:3]([OH:15])=[O:2])=[CH:11][CH:10]=1)(=[O:14])[CH3:13]참가 물질
6
실험 절차
(4-Acetyl-phenylsulfanyl)-acetic acid methyl ester (1.48 g, 6.6 mmol) is dissolved in THF (40 ml). To this solution is added LiOH (415 mg, 9.9 mmol) in water (10 ml), and the mixture was stirred at ambient temperature overnight. The mixture was acidified to pH 5 using 1N HCl and then extracted with ethyl acetate (3×25 ml). The combined organic layers were dried over MgSO4 and concentrated in vacuo to yield (4-acetyl-phenylsulfanyl)-acetic acid as a white solid (1.27 g, 91%).
후처리
- extractionextracted with ethyl acetate (3×25 ml)
- dry with materialThe combined organic layers were dried over MgSO4
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-05a509e742ff42c28946960fd75c152b
- 출처 데이터셋
- uspto-grants-2008_03
- 특허 번호
- US07348359B2
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