Hydrochloric Acid → HCID 20339419, 화합물

HRID 1395459노트

반응식

HRID 1395459 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][N:9]1[CH2:23][CH2:22][N:12]2[C:13]3[C:18]([NH:19][C:20](=[O:21])[CH:11]2[CH2:10]1)=[CH:17][CH:16]=[CH:15][CH:14]=3.O.Cl.[H][H]>O=[Pt]=O.C(O)C>[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[CH2:7][CH2:8][N:9]1[CH2:23][CH2:22][N:12]2[C:13]3[C:18]([NH:19][C:20](=[O:21])[CH:11]2[CH2:10]1)=[CH:17][CH:16]=[CH:15][CH:14]=3

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 203394222,3,4,4a-Tetrahydro-3-[2-(2-Pyridinyl)Ethyl]-1H-Pyrazino[1,2-a]Quinoxalin-5(6H)-OneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 20339419HCID 20339419, 화합물

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 702Ethanol용매

실험 절차

A solution of 2,3,4,4a-tetrahydro-3-[2-(2-pyridinyl)-ethyl]-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one in 120 ml. water and 60 ml. ethanol containing 14 ml. conc. hydrochloric acid, was shaken with 1.2 g. of PtO2 under 45 psi. hydrogen pressure. Solution was filtered, concentrated under vacuum, and residue crystallized once from ethanol and then from methanol. After filtration and drying the dihydrochloride salt of the title compound had a m.p. of 268°-271° C. (dec.); yield: 3.5 g.

후처리

  1. filtrationSolution was filtered
  2. concentrationconcentrated under vacuum, and residue
  3. customcrystallized once from ethanol
  4. filtrationAfter filtration
  5. dry with materialdrying the dihydrochloride salt of the title compound

출처 및 근거

ORD 기록
ord-b8dec87d938f4455b1c7ac8511c4e605
출처 데이터셋
uspto-grants-1980_05
특허 번호
US04203987

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