Hydrochloric Acid → HCID 178465149, 화합물

HRID 1395822노트

반응식

HRID 1395822 반응식
C[O:2][C:3](=[O:77])[C:4](=[CH2:76])[NH:5][C:6](=[O:75])[C@@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[C:12](=[O:74])[C@H:13]([CH2:68][C:69]1[N:73]=[CH:72][NH:71][CH:70]=1)[NH:14][C:15](=[O:67])[C@H:16]([C@H:63]([CH2:65][CH3:66])[CH3:64])[NH:17][C:18](=[O:62])[C@H:19]([CH2:54][C:55]1[CH:60]=[CH:59][C:58]([OH:61])=[CH:57][CH:56]=1)[NH:20][C:21](=[O:53])[C@H:22]([CH:50]([CH3:52])[CH3:51])[NH:23][C:24](=[O:49])[C@H:25]([CH2:42][CH2:43][CH2:44][NH:45][C:46](=[NH:48])[NH2:47])[N:26]([C:30](=[O:41])[CH2:31][N:32]([C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])[CH3:33])[N+:27]([O-:29])=[O:28].[OH-].[Li+].Cl>O1CCOCC1>[C:37]([O:36][C:34]([N:32]([CH2:31][C:30]([N:26]([N+:27]([O-:29])=[O:28])[C@H:25]([C:24]([NH:23][C@H:22]([C:21]([NH:20][C@H:19]([C:18]([NH:17][C@H:16]([C:15]([NH:14][C@H:13]([C:12]([N:8]1[CH2:9][CH2:10][CH2:11][C@H:7]1[C:6]([NH:5][C:4]([C:3]([OH:77])=[O:2])=[CH2:76])=[O:75])=[O:74])[CH2:68][C:69]1[N:73]=[CH:72][NH:71][CH:70]=1)=[O:67])[C@H:63]([CH2:65][CH3:66])[CH3:64])=[O:62])[CH2:54][C:55]1[CH:60]=[CH:59][C:58]([OH:61])=[CH:57][CH:56]=1)=[O:53])[CH:50]([CH3:51])[CH3:52])=[O:49])[CH2:42][CH2:43][CH2:44][NH:45][C:46](=[NH:47])[NH2:48])=[O:41])[CH3:33])=[O:35])([CH3:40])([CH3:38])[CH3:39]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 178465150HCID 178465150, 화합물

생성물 1

HCID 178465149HCID 178465149, 화합물

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

2.09 g of t-butoxycarbonylsarcosylnitroarginylvalyltyrosylisoleucylhistidylprolyldehydroalanine methyl ester is dissolved in 30 ml of dioxane. To this solution is added 60 ml of 1 N lithium hydroxide. The reaction mixture is stirred for three hours, then neutralized with 1 N hydrochloric acid to pH 7. The solvent is removed by vacuum and the residue is dissolved in N,N-dimethylformamide. Ths solution is filtered and the solvent removed by vacuum. The residue is dissolved in dioxane and added to 300 ml of cold rapidly stirring ethyl ether. The precipate is filtered and dried in vacuo to afford t-butoxycarbonylsarcosylnitroarginylvalyltyrosylisoleucylhistidylprolyldehydroalanine.

후처리

  1. customThe solvent is removed by vacuum
  2. dissolutionthe residue is dissolved in N,N-dimethylformamide
  3. filtrationThs solution is filtered
  4. customthe solvent removed by vacuum
  5. dissolutionThe residue is dissolved in dioxane
  6. additionadded to 300 ml of cold rapidly stirring ethyl ether
  7. filtrationThe precipate is filtered
  8. customdried in vacuo

출처 및 근거

ORD 기록
ord-e8940fc6362646668d5fb0de49810923
출처 데이터셋
uspto-grants-1980_05
특허 번호
US04204991

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