Methyl iodide → 6-Bromo-1,3-dimethyl-1H-indole

HRID 1399863

반응식

HRID 1399863 반응식
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:11])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[H-].[Na+].[CH3:14]I>CN(C=O)C>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:11])=[CH:7][N:8]2[CH3:14])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 534029586-Bromo-3-methyl-1H-indole

생성물 1

HCID 233835116-Bromo-1,3-dimethyl-1H-indole

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 6-bromo-3-methyl-1H-indole (200 mg, 0.95 mmol) in DMF (8 mL) was added NaH (114 mg, 2.85 mmol, m %/60%). The mixture was stirred at room temperature for 1 h before the addition of MeI (162 mg, 1.14 mmol). The system was stirred at room temperature for 4 h then the mixture was quenched with water and extracted with EtOAc. The organic layer was concentrated to give crude product which was used in next step without further purification. LCMS (m/z): 224.1 [M+H]+.

후처리

  1. customthe mixture was quenched with water
  2. extractionextracted with EtOAc
  3. concentrationThe organic layer was concentrated
  4. customto give crude product which
  5. customwas used in next step without further purification

출처 및 근거

ORD 기록
ord-46c41d0d9f384c2984f02f3473799030
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08906900B2

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