Ethyl chloroacetate → Glycine, N-(4-chlorophenyl)-, ethyl ester

HRID 1402830

반응식

HRID 1402830 반응식
O.O.O.C([O-])(=O)C.[Na+].Cl[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12].[Cl:16][C:17]1[CH:23]=[CH:22][C:20]([NH2:21])=[CH:19][CH:18]=1>C(O)C>[Cl:16][C:17]1[CH:23]=[CH:22][C:20]([NH:21][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:19][CH:18]=1

참가 물질

5

반응물 3

HCID 7751Ethyl chloroacetateHCID 78124-ChloroanilineHCID 23665404Sodium Acetate Trihydrate

생성물 1

HCID 302644Glycine, N-(4-chlorophenyl)-, ethyl ester수율 55.9%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Sodium acetate trihydrate (6 g) was added to a solution of commercial ethyl chloroacetate (6.2 g) and commercial 4-chloroaniline (6.4 g) in ethanol (5 ml). The mixture was heated to reflux for 5 h. After cooling in an ice bath the product precipitates. The solid was collected by suction filtration and washed with water. The still wet product was recrystallised from ethanol to give ethyl N-(4-chlorophenyl)glycinate (5.99 g) as greyish crystals.

후처리

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 5 h
  3. temperatureAfter cooling in an ice bath the product
  4. customprecipitates
  5. filtrationThe solid was collected by suction filtration
  6. washwashed with water
  7. customThe still wet product was recrystallised from ethanol

출처 및 근거

ORD 기록
ord-f4611cbfb3fb4deea75c22e6bec2aa55
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08912186B2

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