Hydrochloric Acid → HCID 178509540, 화합물

HRID 1404907노트

반응식

HRID 1404907 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1Cl)[C:5]#[N:6].[C:11](=[S:16])(OCC)[S-:12].[K+].Cl>CN(C=O)C.O>[C:5]([C:4]1[CH:7]=[CH:8][C:9]2[S:12][C:11]([SH:16])=[N:1][C:2]=2[CH:3]=1)#[N:6]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 1044643-Amino-4-chlorobenzonitrileHCID 2735045Potassium ethylxanthate

생성물 1

HCID 178509540HCID 178509540, 화합물수율 76.1%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

반응 조건

온도
115 °C

실험 절차

A mixture of 3-amino-4-chloro benzonitrile (13, 0.50 g, 3.28 mmol) and potassium O-ethyl dithiocarbonate (1.05 g, 6.55 mmol) in DMF (15 mL) was heated overnight at 110-120° C. under N2. After cooling, the reaction mixture was diluted with water and acidified with 1N HCl. The precipitate was collected by filtration, washed with water, and dried under vacuum to yield 14 (0.48 g, 76%).

후처리

  1. temperatureAfter cooling
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-58491280b04643bcbe6067d240e6a43f
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08916550B2

반응 노트

불러오는 중…