Hydrochloric Acid → 2-(Benzo[d]thiazol-2-yloxy)acetic acid

HRID 1404942노트

반응식

HRID 1404942 반응식
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[O:10][CH2:11][C:12]([O:14]CC)=[O:13].[OH-].[Na+].Cl>CO>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[O:10][CH2:11][C:12]([OH:14])=[O:13]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 59467898HCID 59467898, 화합물

생성물 1

HCID 2435072-(Benzo[d]thiazol-2-yloxy)acetic acid수율 86%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 60 (1.32 g, 5.6 mmol) in MeOH was added NaOH (3M, 75 mL, 0.22 mol) dropwise. The mixture was stirred at room temperature over night. It was then cooled in an ice-water bath and acidified to pH<2 with HCl (2N). The mixture was then extracted with CHCl3 (3×). The combined organic layers were dried over Na2SO4 and concentrated in vacuum to yield 61 as a white solid (1.0 g, 86%).

후처리

  1. temperatureIt was then cooled in an ice-water bath
  2. extractionThe mixture was then extracted with CHCl3 (3×)
  3. dry with materialThe combined organic layers were dried over Na2SO4
  4. concentrationconcentrated in vacuum

출처 및 근거

ORD 기록
ord-506823504202427ba8fc1d607fb1f1c8
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08916550B2

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